My research focuses on the effects of chemicals with differing toxic mechanisms on the long-term health of aquatic animals, primarily fish. Current efforts involve a class of toxicants broadly labeled endocrine-disrupting chemicals (EDCs) that cause a wide range of adverse effects on development and reproduction that can lead to substantial population-level impacts. This research involves conventional toxicology approaches (e.g., whole animal tests) used in conjuntion with state-of-the-art genomic, bioinformatic and computational tools.
Perkins, E.J., N. Garcia-Reyero, D.L. Villeneuve, D. Martinovic, S.M. Brasfield, L.S. Blake, J.D. Brodin, N.D. Denslow and G.T. Ankley. 2008. Perturbation of gene expression and steroidogenesis with in vitro exposure of fathead minnow ovaries to ketoconazole. Mar. Environ. Res. In press.
Villeneuve, D.L., I. Knoebl, P. Larkin, A.L. Miracle, B.J. Carter, N.D. Denslow and G.T. Ankley. 2008. Altered gene expression in the brain and liver of female fathead minnows exposed to fadrozole. J. Fish Biol. In press.
Villeneuve, D.L., L.S. Blake, J.D. Brodin, J.E. Cavallin, E.J. Durhan, K.M. Jensen, M.D. Kahl, E.A. Makynen, C. Martinovic. N.D. Mueller and G.T. Ankley. 2008. Effects of a 3β-hydroxysteroid dehydrogenase inhibitor, trilostane, on the fathead minnow reproductive axis. Toxicol. Sci. In press.
Wang, R.-L., D. Bencic, A. Biales, D. Lattier, M. Kostich, D. Villeneuve, G.T. Ankley, J. Lazorchak and G. Toth. 2008. DNA microarray-based ecotoxicological discovery in a small fish species. Environ. Toxicol. Chem. 27, 664-675.
Wang, R.-L., A. Biales, D. Bencic, D. Lattier, M. Kostich, D. Villeneuve, G.T. Ankley, J. Lazorchak and G. Toth. 2008. DNA microarray application in ecotoxicology: experimental design, microarray scanning, and factors impacting transcriptional profiles in a small fish species. Environ. Toxicol. Chem. 27, 652-663.